Cellular Immunology Lab
Department of
Life Science, Chung-Ang University, 84 Heuksuk-ro, Dongjak-gu Seoul,
06974, Korea
Research
Interests
- The role of plasma membrane fluidity
in cell-cell interaction
- The regulation of antigen
presentation in dendritic cells
- Immune response against the chronic
viral infection
- The development of anti-viral drugs
- The development of vaccines for the
influenza virus
Lab
Members
Principal
Investigator
Young-Jin Seo, Ph.D.
Postdoctoral Fellow
Yong-Bin Cho, Ph.D.
Ph.D. Course Students
Younghyun Lim, M.S.
In-Gu Lee, M.S.
Master Course Students
Jeongnghyun Lee, B.S.
Hyung-Rae Kim, B.S.
Alumni
Seyoung Kim, M.S. (2018-2020)
Ji-Hun Kang, M.S. (2019-2021)
Dongin Kim, M.S. (2019-2021)
Yong-Hyun Joo, M.S.
(2020-2022)
Hoyeon Jeon, M.S.
(2021-2023)
Publications
2023
• Do-Hyung Kim, Daegi An, Yoon-seob Kim, Younghyun Lim, Young-Jin Seo, Hak Kyun Kim, Ho-Young Kang, Animal Cells and Systems
(2023)
•
In-Gu Lee, Jeonghyeon Lee, So-Hee Hong*, Young-Jin Seo*, Apigenin’s therapeutic potential
against viral infection, Frontiers in Bioscience-Landmark,
(2023), *Corresponding author
•
Junyoung
Park, Yongyang Luo, JinWoo Park, Song Hyun Kim, Ye Joo Hong, Younghyun Lim, Young‑Jin Seo, Jeehyeon Bae,
Sang Beom Seo, Scientific Reports (2023)
• In-Gu Lee# Yong-Hyun
Joo# Hoyeon Jeon,
Jung-Woong Kim, Young-Jin Seo, So-Hee
Hong, Disruption of type I interferon pathway and reduced production
of IFN‑α by parabens in virus‑infected dendritic cells, Genes
& Genomics (2023), #Co-first
• Yang Joo Kang, Deuk-Su Kim, Seyoung Kim, Young-Jin Seo, Kisung Ko,
Plant-derived PAP proteins fused to immunoglobulin A and M Fc domains induce
anti-prostate cancer immune response in mice, BMB Reports (2023)
• In-Gu Lee, Yong-Hyun
Joo, Hoyeon Jeon, Raehyuk Jeong, Eui Ho Kim, Hyunwoo Chung, Seong-il Eyun,
Jeongkyu Kim*, Young-Jin Seo*, and
So-Hee Hong*, Galectin-4 increases the ability of M2 macrophages to enhance
antiviral CD4+ T cell responses, Journal of Leukocyte Biology
(2023), *Corresponding author
2022
• Chunha Shin,
Kibum Kim, Yang Joo Kang, Deuk‑Su Kim, Young‑Jin Seo, Se Ra Park,
Mi Kyung Kim, Young Koung Lee, Do‑Sun Kim,
Kisung Ko, Efect of IgG Fc‑fusion and KDEL‑ER retention signal
on prostate‑specifc antigen expression in plant and its immune
in mice, Plant Biotech Rep (2022).
• Hoyeon Jeon, Younghyun Lim, In-Gu Lee, Dong-In Kim,
Keun Pil Kim, So-Hee Hong, Jeongkyu Kim*, Youn-Sang Jung*, and Young-Jin Seo*, Inhibition of KIF20A
suppresses the replication of influenza A virus by inhibiting viral entry,
Journal of Microbiology (2022),
*Corresponding
author
•
Yong-Hyun Joo, Yeong-Geun Lee, Younghyun
Lim, Hoyeon Jeon, In-Gu Lee, Yong-Bin Cho, So-Hee Hong, Eui
Ho Kim, Soon Ho Choi, Jung-Woong Kim*, Se Chan Kang*, and Young-Jin Seo*,
Anti-influenza A virus activity by Agrimonia
pilosa and Galla rhois
extract mixture,
Biomedicine & Pharmacotherapy (2022), *Corresponding author
• Jimoon Jun, Hyeon Gyeong
Jeong, Hyeongwoo Choi, Hyunmin Woo, Donggu Jeon, Young-Jin
Seo* and Seong-il Eyun*, The complete mitochondrial genome of Labidocera
rotunda Mori, 1929 (Copepoda: Calanoida) from Jeju Island, Korea, MITOCHONDRIAL
DNA PART B (2022), *Corresponding author
• Da Min Jeong, Su Jin Yoo, Min-Seung Jeon,
Byung Hee Chun, Che Ok Jeon, Seong-il Eyun, Young-Jin
Seo and
Hyun Ah Kang, Genomic
features, aroma profiles, and probiotic potential of Debaryomyces hansenii
complex strains isolated from Korean soybean fermented food, Food
Microbiology (2022)
• Se Min Cho, Dae Won Park,
Yeong-Geun Lee, Yong Joon Jeong, Hyelin Jeon, Young-Jin
Seo*, Hyunggun Kim*, Se Chan Kang*, Anti-varicella zoster virus and
related anti-inflammation effects of ethanolic extract of Elaeocarpus
sylvestris, Journal of Ethnopharmacology (2022), *Corresponding
author
• Seung-Won Yun#, Young-Jin Seo#, Jeong Eun Kwon, Dae
Won Park, Yeong-Geun Lee, Tae Hwan Choe, Seul-Ki Kim, Hak Sung Lee, Hyunggun
Kim, Se Chan Kang, Preclinical evaluation of Zanthoxylum piperitum Benn.,
traditional muscle pain remedy, for joint inflammation, Journal of Ethnopharmacology
(2022),
#Co-first
•
Yong-Hyun Joo, Yeong-Geun Lee, Younghyun
Lim, Hoyeon Jeon, Eui Ho Kim,
Joongyeon Choi, Woojae Hong, Hyelin Jeon, Michael Ahrweiler, Hyunggun Kim*,
Se Chan Kang*, and Young-Jin Seo*, Potent antiviral activity of the extract of
Elaeocarpus sylvestris against influenza A virus in vitro and in
vivo, Phytomedicine (2022), #Co-first,
*Corresponding author
2021
• Yeong-Geun Lee,
Kyung Won Kang, Woojae Hong, Yeon Hwa Kim, Jen Taek Oh, Dae Won Park, Minsung
Ko, Yun-Feng Bai, Young-Jin Seo*, Sang-Myeong
Lee*, Hyunggun Kim*, and Se Chan Kang*, Potent antiviral activity of Agrimonia
pilosa, Galla rhois, and their components against SARS-CoV-2, Bioorganic
& Medicinal Chemistry (2021), *Corresponding author
•
Ji-Hun Kang#, Hyun Joo Lee#, Ok-Hyeon
Kim, Yong Ju Yun*, Young-Jin Seo*, Hyun Jung Lee*, Biomechanical
forces enhance directed migration and activation of bone marrow-derived
dendritic cells, Scientific Reports (2021), #Co-first, *Corresponding
author
• Dong-In Kim#, Ji-Hun Kang#, Eui-Ho Kim, Young-Jin Seo*, KIF11 inhibition decreases
cytopathogenesis and replication of influenza A virus, Molecular &
Cellular Toxicology (2021) #Co-first, *Corresponding
author
• Minho Lee#, Minju Joo#, Minkyung Ryu#, Young-Jin Seo#,
Jaejin Lee, Hong-Man Kim, Ji-Hyun Yeom, Yong-Hak Kim, Jeehyeon Bae, and
Kangseok Lee, Endoribonucleases-mediated modulation of hns mRNA stability enhances Salmonella
Typhimurium pathogenicity in
the host environment, PloS Pathogens (2021) #Co-first
•
Dong-In Kim, Yong-Bin Cho, Younghyun Lim, So-Hee Hong, Bumsuk Hahm, Sang-Myeong Lee, Se Chan Kang, Young-Jin
Seo*, Chios mastic gum inhibits influenza A virus replication and viral
pathogenicity, Journal of General Virology (2021) *Corresponding
author
2020
•
Yong-Bin Cho,
In-Gu Lee, Yong-Hyun Joo, So-Hee Hong*, Young-Jin Seo*, TCR Transgenic
Mice: A Valuable Tool for Studying Viral Immunopathogenesis Mechanisms, International
Journal of Molecular Sciences (2020), *Corresponding author
• Caleb
J. Studstill#, Curtis J. Pritzl#, Young-Jin Seo#,*,
Dae Young Kim, Chuan Xia, Jennifer J. Wolf, Ravi Nistala, Madhuvanthi Vijayan, Yong-Bin Cho,
Kyung Won Kang, Sang-Myeong Lee, and Bumsuk Hahm*, Sphingosine kinase 2 restricts T cell immunopathology but permits viral
persistence, Journal of
Clinical Investigation (2020), #Co-first,
*Corresponding author
• Eui-Hwan
Choi, Seobin Yoon, Young Eun Koh, Young-Jin Seo,
and Keun Pil Kim, The Maintenance of Genome Integrity and
Homologous Recombination in Embryonic Stem Cells, Exp Mol Med (2020).
•
Younghyun Lim#, Seyoung Kim#, Sehoon Kim, Dong-In Kim,
Kyung Won Kang, So-Hee Hong, Sang-Myeong Lee, Hye Ran Koh*, Young-Jin
Seo*, N-3
Polyunsaturated Fatty Acids Impede the TCR Mobility and the TCR–pMHC
Interaction of Anti-Viral CD8+ T Cells, Viruses (2020) #Co-first, *Corresponding author
•
Yong-Bin Cho#, Sungguan Hong#, Kyung-Won Kang, Ji-Hun Kang, Sang-Myeong Lee*, Young-Jin Seo*, The
inhibition of kinesin family member KIF18A expression attenuates the
replication of influenza A virus, J Cell Mol Med (2020), #Co-first, *Corresponding author.
•
Hansaem Kim, Jaeyong Kang, Seungwoo
Hong, Seonyeong Jo, Hyangsoon Noh, Byung-Ha Kang, Suhyun Park, Young-Jin Seo*, Kwang-Hoon Kong*, Sungguan Hong*, 3M-Brazzein as a natural sugar
substitute attenuates obesity, metabolic disorder, and inflammation, J
Agri Food & Chemistry, (2020) *Corresponding author
• Eunae You, Panseon Ko, Jangho Jeong, Seula Keum, Jung-Woong Kim, Young-Jin Seo, Woo Keun Song, and Sangmyung Rhee, Dynein-mediated nuclear
translocation of yes-associated protein through microtubule aceylation controls
fibroblast activation, Cell Mol Life Sci, (2020).
•
Mi Jin Kim#,
Chul-Hong Kim#, Young-Jin Seo#, Mi-Jin An,
Ju-Hyun Lee, Geun-Seup Shin, Jae Yoon Hwang,
Jinhong Park, Ji-Young Kim, Seung Yong Hwang,
Sangmyung Rhee, Jung-Woong Kim, Transcriptome dynamics of alternative splicing events revealed
early phase of apoptosis induced by methylparaben in H1299 human lung carcinoma
cells, Archives of Toxicology, (2020) #Co-first.
•
Seyoung Kim#, Yong-Bin Cho#, Chi-hoon Song, Seong-Il Eyun*, Young-Jin Seo*, Kinesin family member
KIF18A is a critical cellular factor that regulates the differentiation and
activation of dendritic cells, Genes & Genomics (2020), #Co-first, *Corresponding author.
•
Seyoung Kim, Sung-Jin Cho, Ju-Young
Lee, Younghyun
Lim, Soon Cheol Park*, Young-Jin Seo*, Upregulation of cellulase activities by the
bacterial challenge in the earthworm, Eisenia
andrei, BBRC (2020) *Corresponding
author.
~2019
•
Dae Won Park, Young Min Ham, Rina So, Young Jin Seo*,
Se Chan Kang*, Multioside, an active ingredient from Adonis amurensis, displays
anti-cancer activity through autophagosome formation, Phytomedicine (2019) *Corresponding author.
•
Jeong Eun Kwon, Yeong-Geun Lee, Ji-Hun Kang, Nam-In Baek, Young-Jin Seo* and Se Chan Kang*, Anti-viral activity
of compounds from Agrimonia pilosa and Galla rhois extract mixture, Bioorganic chemistry (2019) *Corresponding author.
•
Kyung Won Kang#,
Seyoung Kim#, Yong-Bin Cho, Seung Rok Ryu, Young-Jin Seo*, Sang-Myeong Lee*, Endogenous n-3
polyunsaturated fatty acids are beneficial to dampen CD8+ T cell-mediated
inflammatory response upon the viral infection, International Journal of
Molecular Sciences (2019), #Co-first, *Corresponding author.
•
Chuan Xia#, Young-Jin Seo#, Caleb J. Studstill, Madhuvanthi
Vijayan, Jennifer J. Wolf, and Bumsuk Hahm, Transient inhibition of sphingosine
kinases confers protection toinfluenza A virus infected mice, Antiviral Research (2018)
*Co-first, (2018) Oct;158:171-177.
•
Renan Aguilar-Valenzuela, Jason
Netland, Young-Jin
Seo, Arash Grakoui, and Mehul Suthar,
Dynamics of tissue-specific CD8+ T cell responses during West Nile virus
infection. Journal of Virology (2018)
•
Young-Jin Seo#, Prithiviraj Jothikumar#, Mehul Suthar, Cheng Zhu, and
Arash Grakoui, Local cellular and cytokine cues in the spleen regulate in situ
T cell receptor affinity, function, and fate of CD8+ T cells. Immunity
(2016) #Co-first.
•
Curtis J. Pritzl, Young-Jin Seo, Chuan Xia, Madhuvanthi Vijayan, Zachary D. Stokes, and Bumsuk
Hahm, A ceramide analogue displays stimulatory activity on dendritic cells to
promote T cell responses upon virus infection. Journal of Immunology
(2015)
•
Young-Jin Seo and Bumsuk Hahm, Sphingosine analog AAL-R increases activation of
LCMV-infected dendritic cells, Viral Immunology (2014)
•
Madhuvanthi Vijayan, Young-Jin Seo, Curtis John Pritzl, Sarah Angela Squires, Stephen Alexander, and
Bumsuk Hahm, Sphingosine kinase regulates measles virus replication, Virology
(2014)
•
Daniel J Howard, Young-Jin Seo, Bumsuk Hahm and Jae Wan Kwon, A Microfluidic Device with Concave
Surfaced Micropost Array for Rare Cell Capture, IEEE Sensors Journal (2014)
•
Young-Jin Seo, Curtis J. Pritzl,
Madhuvanthi Vijayan, Kavita Bomb, Mariah E. McClain, Stephen Alexander, and
Bumsuk Hahm, Sphingosine kinase 1 serves as a pro-viral factor regulating NF-κB
and RanBP3 activation upon influenza virus infection, Plos One (2013)
•
Curtis J. Pritzl, Young-Jin Seo, and Bumsuk Hahm, Viruses strive to suppress host immune
responses and prolong persistence, Book Title: Recent Advances in Immunology to
Target Cancer, Inflammation and Infections, Dr. Jagat Kanwar (Ed.) InTech
(2012)
•
Young-Jin Seo, Curtis J.
Pritzl, Madhuvanthi Vijayan, Celeste R. Blake, Mariah E.
McClain, and Bumsuk Hahm, Sphingosine analog AAL-R increases TLR7-mediated
dendritic cell responses via p38 and type I IFN signaling pathways, Journal
of Immunology (2012)
•
Young-Jin Seo, Stephen Alexander,
and Bumsuk Hahm, Does cytokine signaling link sphingolipid metabolism to host
defense and immunity against virus infections? Cytokine Growth Factor Rev (2011)
•
Yeon-Joo Yook, Young-Jin Seo, Hyoung Jin Kang, Sang-Hyeok Ko, Hee Young Shin, Jeong Jin Lee,
Gajin Jeong, and Hyo Seop Ahn, The induction of hypoxia-inducible factor- 1α
inhibits drug-induced apoptosis in the human leukemic cell line HL-60, Korean
J Hematol (2010)
•
Young-Jin Seo and Bumsuk Hahm, Type I interferon modulation of host immune
system battling with invading viruses, Adv Appl Microbiol (2010)
•
Young-Jin Seo, Celeste R. Blake,
Steven Alexander, and Bumsuk Hahm, Sphingosine 1- phosphate-metabolizing
enzymes control influenza virus propagation and viral cyto- pathogenicity, Journal
of Virology (2010)
•
Hyoung Jin Kang, Ji Won Lee, Sang Hyeok
Kho, Min Jeong Kim, Young Jin Seo, Hee Young Shin,
Hyo Seop Ahn, High transcript level of FLT3 associated with poor prognosis in
pediatric acute myeloid leukemia, J Korean Med Sci (2010)
•
Hyoung Jin Kang, Yongtaek Oh, Sung-Min
Chun, Young
Jin Seo, Hee Young Shin, Chul Woo Kim, Hyo
Seop Ahn, Byoung-Don Han, TotalPlex gene amplification using bulging primers
for pharmacogenetic analysis of acute lymphoblastic leukemia, Mol
Cell Probes (2008)
•
Young-Jin Seo#, Sang Hyeok Koh#, Hyoung Jin Kang, Hee Young Shin,
Gajin Jeong, Hyo Seop Ahn, Hypoxia inhibits the SDF-1-dependent migration of
human leukemic cell line HL-60 via blocking of Akt activation, Biochem
Biophys Res Commun (2007)
Updated on 2023/2/03